News and Insights of 3D Printing and Manufacturing
Finnish bioprinting startup Brinter released the new extrusion-based Visco Bio medical print head for its Brinter bioprinters. The new modular print heads enable nearly zero dead volume, meaning that expensive medical grade material waste is cut to a minimal level. The Finnish company continues to develop and implement new features to its device on the back of a strong first year’s growth year in 2021.
Prellis Biologics Inc., a biotherapeutics company with human tissue engineering capabilities, has entered into a collaboration and license option agreement with Sanofi S.A., an innovative global healthcare company. The collaboration will focus on the discovery of antibodies with Prellis’ first-in-class external human immune system (EXIS), and leverages Prellis’ ability to engineer fully-human lymph node organoids (LNOs) and recreate immune responses in vitro to deliver antibodies with significant genetic diversity.
Carl Zeiss Meditec, one of the world’s leading medical technology companies, and Precise Bio, a regenerative medicine company advancing the use of bio-printed tissues and organs, have entered into a partnership to develop and commercialize fabricated corneal tissue for transplants in patients that require endothelial keratoplasty and natural lenticule transplants for treating keratoconus and vision correction.
Finland-based bioprinting firm Brinter has launched what it claims is the world’s first multi-material, multi-fluidic bioprinting printhead.
Biotechnology firm United Therapeutics has showcased what it claims to be the “world’s most complex 3D printed object” in partnership with 3D printer manufacturer 3D Systems at the recent LIFE ITSELF conference in San Diego.
Humabiologics, an industry leader in providing human-derived biomaterials for regenerative medicine, founded by scientists and tissue industry experts to address the gap between the gift of donated human tissues and researchers, and Fisher Scientific, a global leader in life sciences, are partnering to serve researchers in academia and industry who are working on regenerative medicine research.
3D bioprinting firm BICO’s board has thrown its weight behind the company’s under-fire CEO Erik Gatenholm after mismanagement allegations being raised against him by a former employee and anonymous sources.
Israeli regenerative medicine firm Matricelf has reached a new milestone in the development of its 3D printed neural implants for paralyzed patients with spinal cord injuries.
Canadian 3D bioprinting firm Aspect Biosystems has unveiled a new partnership with the international diabetes research and advocacy organization JDRF.
Formlabs introduced the new BioMed Black Resin and BioMed White Resin, two highly opaque medical-grade materials targeted for use in biocompatible applications.
Regenerative medicine specialist CollPlant (NASDAQ: CLGN) has revealed that the 3D bioprinted breast tissues it’s developing are set to enter animal trials in the very near future.
Swedish bioprinting company Fluicell launched its second single-cell 3D bioprinter: the new Biopixlar AER is a compact 3D bioprinter that lets users create detailed biological tissues with high precision. It is the world’s first microfluidic high-precision bioprinter that fits inside a standard flow hood or biosafety cabinet. Fluicell designed it for high automation and easy workflow integration, with the goal of bringing Biopixlar technology to new customer segments.
Remember when, in 2017, scientists 3D printed an artificial ovary and implanted it into a sterile mouse, which later gave birth to healthy pups? Now, science has gone one step further by 3D printing testicular cells – showing promising early signs of sperm-producing capabilities.
Finland-based bioprinting firm Brinter, together with extrusion technology developer Puredyne, has announced the launch of its new Visco Bio printhead for use with its 3D bioprinters.
Nanoscribe and CELLINK, two BICO companies, today jointly unveiled the Quantum X bio, a revolutionary system as part of the Nanoscribe Quantum X platform providing researchers with a very accurate 3D bioprinter. The Quantum X bio is the first-of-its-kind bioprinter enabling submicron printing resolution. Powered by Two-Photon Polymerization (2PP), the Quantum X bio is the premier tool for miniaturizing bioprinting to redefine the development of complex tissue or cell scaffolds and of advanced biomedical applications.
Bioprinter manufacturer REGEMAT3D is launching a new equity crowdfunding round, that will help the company further scale its business and product lines while preparing for an IPO set to take place in 2023. At 3dpbm we usually do not cover crowdfunding campaigns for new products, however, this initiative is relative to a company that is already present in the market and has been making significant progress in the bioprinting segment. REGEMAT3D promises massive returns (up to 3 to 4 times the investment) and while the actual success of this financial initiative is subject to the same risks as any financial venture, the overall bioprinting segment is in fact growing up rapidly.
Bioprinting startup Brinter has today announced a partnership with LED Tailor to introduce the new Spectral Blue disinfecting blue light feature embedded in its multi-material 3D bioprinting solution Brinter. The system enables the safe production of e.g. tissue models and drugs, and minimizes the need for separate cleanrooms, making bioprinters more portable and safe.
3D bioprinting firm BICO has announced an initial $1.5 million contract manufacturing deal with regenerative joint replacement start-up Nanochon.
Biotechnology firm Prellis Biologics has announced the closure of a $14.5 million Series B funding round alongside the creation of a novel antibody discovery platform.
The NOVOPLASM consortium has announced it is the “first in the world” to develop cold plasma technology for the treatment of infected burns and the wound healing of skin grafts.
Regenerative medicine firm CTIBIOTECH has developed a new 3D bioprinting platform to deliver personalized medicine for patients with colorectal cancer.
Bioconvergence company BICO is partnering with Nanochon, a startup developing regenerative joint replacements. Under the terms of the deal, Nanochon will purchase $1.5 million worth of products and services from BICO’s SCIENION to develop 3D printed regenerative joint implants. Nanochon’s novel joint implant technology promises to deliver faster and more successful recoveries for patients while reducing costs to health providers, payers, and patients.
Scientists at the Irish RCSI University of Medicine and Health Sciences have developed a novel bio-ink that can be 3D printed into tissues capable of fast-forwarding the human wound-healing process.
Fluicell, a Sweden-based bioprinting startup founded in 2012 as a spin-out of the Chalmers University of Technology, has undertaken research to develop medicinal products for treating type 1 diabetes. The project, which recently achieved a significant milestone, is based on biocomposite tissues generated by Fluicell’s Biopixlar system.
Bioprinting company T&R Biofab and B Braun, a major healthcare solutions provider, held a joint presentation to launch T&R’s new 3D printed PCL Craniofacial bone implants products. The event, hosted by B Braun Korea was held at the Dragon City Hotel in Seoul.
The PhonoGraft biomimetic hearing-restoration technology, advanced through a six-year effort by a multidisciplinary research team at the Wyss Institute for Biologically Inspired Engineering, Harvard’s John A. Paulson School of Engineering and Applied Sciences (SEAS), and Massachusetts Eye and Ear (MEE)/Mass General Brigham (MGB), has now entered commercial development. If successful, it could mitigate pain, drainage, and hearing loss associated with eardrum perforations that affect millions of individuals worldwide.
Nominations for the 2021 3D Printing Industry Awards are now open, have your say who is leading the industry now.
FluidForm, an expert in the field of human tissue for research, repair, and replacement signed an agreement with Ethicon, a member of the Johnson & Johnson Medical Devices Companies, to develop 3D bioprinted applications using FluidForm’s patented FRESH technology. This collaboration leverages FluidForm’s FRESH 3D bioprinting platform to achieve specific tissue characteristics that cannot be manufactured with conventional techniques.
3D printer manufacturer 3D Systems has announced a co-development agreement with CollPlant, a regenerative medicine firm, to develop 3D bioprinted soft tissue structures for breast reconstruction treatments.
Researchers at the Baylor College of Medicine used a 3D bioprinter to fabricate a Biomesh using a polymer called phosphate cross-linked poly (vinyl alcohol) polymer (X-PVA) for an innovative new treatment of hernias. The complete study was published in Advanced Materials.
Advanced Development of Additive Manufacturing (A.D.A.M.) is on the cusp of releasing 3D-printed bioresorbable bone implants. The implants would, if successful, be completely absorbed by the body. Recovery times would improve; patients would undergo fewer surgeries; the implant is personalized to each patient.
3D Bioprinting Solutions, a Russian bio-technical research laboratory, has 3D bioprinted bone tissue in zero gravity on the International Space Station (ISS).
Scientists from the Human Genome and Stem Cell Research Center (HUG-CELL) University of São Paulo (USP), have utilized 3D bioprinting to develop functional hepatic organoids, otherwise known as mini-livers.
GE Healthcare Life Sciences and Advanced Solutions Life Sciences (ASLS), a Kentucky-based biotechnology firm, are collaborating to build an integrated 3D bioprinter by combining their respective technologies.
San Francisco biotechnology company Prellis Biologics has launched a web-based platform for the generative design and download of 3D printable tissue scaffolds. Named TissueWorkshop™, the platform has been created to reduce the amount of time required to create such structures, freeing experts from labor-intensive design cycles.
Scottish biomaterial developer, Biogelx, and Regemat 3D, a Spain manufacturer of bioprinting systems, have partnered to develop a new skin model as well as offering complete bioprinting solutions for research institutes worldwide.
Scientists from Carnegie Mellon University (CMU), Pennsylvania, have used a novel 3D bioprinting method to build functional parts of the human heart.
CollPlant, an Israeli 3D bioprinting and regenerative medicine firm, has announced that it is developing implants for breast tissue regeneration. After conducting early development, the company has successfully produced the first prototypes. It believes that these 3D bioprinted breast implants could have the potential to provide a safer alternative to the standard methods of permanent breast implantation.
Scientists from medical tech company Fluicell have partnered with clinical R&D firm Cellectricon and the Swedish Karolinska Institutet university to 3D bioprint neural cells into complex patterns.
Population aging is one of Europe’s great challenges in the 21st century. By 2024, 22% of Europeans are expected to be over 65. Patients suffering from chronic joint detop fects or defects in the oral and maxillofacial regions have a significantly reduced quality of life and are continually dependent on health care. The Covid-19 crisis has shown how dangerous chronically overcrowded hospitals and large cohorts of care-dependent and risk-grouped patients can become. Therefore, science and technology must work together to ensure that living longer can be synonymous with living well. INKplant, a project funded by the European Union H2020, was conceived to face this challenge and democratize its new solutions.
American multinational consumer goods company Procter & Gamble (P&G) has signed a 3D bioprinting research and development agreement with San Francisco biotechnology company Aether.
ROKIT Healthcare, a Korean 3D bioprinter manufacturer previously known as ROKIT, has introduced a novel 3D bioprinting method to treat scarred lesions.
Researchers at St. Mary’s Hospital in Seoul, South Korea, have applied 3D printing to the treatment of a condition that can cause respiratory problems and sleep disorders. In a clinical study, the team used 3D printing to develop a biocompatible splint that could be inserted into the nose and help correct a deviated septum. In 20 volunteer patients, aged 18-74, the 3D printed device proved to outperform other artificial splints.
Swedish 3D bioprinter manufacturer CELLINK has agreed to acquire the in-vitro technology specialist MatTek Corporation for $68 million.
Researchers from the University of Wollongong (UOW) ARC Centre of Excellence for Electromaterials Science (ACES) in Australia, have developed a customizable 3D bioprinter, 3D Alek, to combat congenital ear deformity.
Scientists from the Foundation for Research and Science Development in Poland (Fundacja Badań I Rozwoju Nauki or Fundacja BIRN) are using 3D bioprinting to create a bionic pancreas.
CELLINK, the Swedish manufacturer of the BIO X 3D printer, and Volumetric a Texas-based biomaterials and biomanufacturing company, have introduced the Lumen X Digital Light Processing (DLP) bioprinter to produce large vascular structures.
South Korean scientists are working to improve cancer treatments with 3D bioprinting.
Philadelphia-headquartered 3D bioprinting company Allevi has launched the Skin Bioink Kit. A material package, this kit is to be used in conjunction with its 3D bioprinters to produce patches of skin. It aims to allow tissue engineers to design multi-layered skin patches that are more akin to natural human skin.
Scientists from the University at Buffalo have developed a rapid new 3D bioprinting method that could represent a significant step towards fully-printed human organs.
CD3D Medical, the R&D arm of Polish 3D printing news provider CD3D Sp. z. o. o. (Centrum Druku 3D) has created an Open 3D Bioprinting Cluster in Lodz. Part of the Bionanopark laboratory complex, this facility, according to the company, is one of largest of its kind in Europe, housing 21 SKAFFOSYS 3D bioprinters developed specially for this purpose.
Engineers from McMaster University in Hamilton, Canada, have developed a 3D bioprinting method using magnets to rapidly produce cell clusters.
Researchers from the Massachusetts Institute of Technology (MIT) have used fine-scale 3D bioprinting and melt electrowriting to grow highly uniform cell cultures.
Poietis, a French biotechnology company, has announced the granting of a third patent for its laser-assisted 3D bioprinting method.
Readily3D, a manufacturer of volumetric 3D bioprinters, has announced its participation in the European ENLIGHT project.
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Two postdoctoral researchers at UC Santa Barbara, Renxuan Xie and Sanjoy Mukherjee, developed the first 3D-printable “bottlebrush” elastomer. The new material results in printed objects that have unusual softness and elasticity that closely resemble those of human tissue. The researchers’ findings were published in the journal Science Advances.
Researchers at the University of Stuttgart and Robert Bosch Hospital are developing a novel 3D printed tissue platform that could replace animal testing in clinical trials.
Pandorum Technologies Pvt., a Bangalore-based biotechnology company, has used 3D bioprinted cornea tissue to promote scarless healing of wounds in the eye.
Canadian 3D bioprinting technology company Aspect Biosystems has announced its involvement in a $2.2 million project seeking to find new treatments for cancer. Starting this year, the company will be working with collaborators at two of the world’s largest pharmaceutical companies Merck and GSK, as well as McGill University’s Goodman Cancer Research Centre in Quebec.
The 3D BioFabrication Facility (BFF) bioprinter from nScrypt, a Florida-based 3D printing system manufacturer, and spaceflight equipment developer Techshot is set to launch on the International Space Station (ISS) next month.
Korean biotechnology companies T&R Biofab and SCM Life Science are to collaborate on the R&D of new 3D printed tissue regenerative products. The two companies will focus on marketable cell patch products and new formulations for cell therapy.
Aleph Objects, the manufacturer of LulzBot open source 3D printers, has confirmed its entry into the 3D bioprinting market. In partnership with Massachusetts based 3D bioprinting technology developer FluidForm, Aleph plans to launch LulzBot Bio hardware later this year.
3D Systems significantly expanded its focus on regenerative medicine and bioprinting solutions after reducing its workforce to concentrate on the healthcare AM sector. The expanded focus follows on great progress made in the development of 3D printing systems for solid-organ scaffolds. This progress is the product of collaboration between 3D Systems, United Therapeutics Corporation and UTC’s organ manufacturing and transplantation-focused subsidiary, Lung Biotechnology PBC. 3D Systems intends to leverage this work and accomplishments with other partners to invest, further develop and commercialize solutions for regenerative medicine. Applications of its R&D program include the development of non-solid organ applications requiring biologically sustainable vasculature.
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Swedish 3D bioprinter and materials developer CELLINK has announced the launch of BIO X6, a new six-printhead bioprinting system that allows the combination of multiple materials, cells and tools. It also features an intelligent exchangeable printhead system and CELLINK’s patented Clean Chamber Technology to enhance advanced research and clinical applications.
The Queensland University of Technology (QUT) in Brisbane, Australia, and Shanghai-based researchers, including the Chinese Academy of Sciences, have received $300,000 to establish a 3D bioprinting research centre.
Leading 3D printer OEM 3D Systems has announced a partnership with Antleron, a Belgium-based biotechnology company, to develop regenerative products for personalized patient care.
Biomedical researchers from Texas Tech University Health Sciences Center El Paso (TTUHSC El Paso) and The University of Texas at El Paso (UTEP) are collaborating to develop artificial mini-hearts using 3D bioprinting technology for space.
Leading 3D printer OEM 3D Systems and Israeli bioprinting material developer CollPlant have announced a joint development agreement seeking to create tissue and scaffold bioprinting solutions for third party collaborators.
A worldwide collective of researchers and scientists from universities, institutions, and hospitals have come together to produce a roadmap for 3D bioprinting.
Researchers from the University of Toronto (UoT) and Sunnybrook Health Sciences Centre have developed a handheld device capable of 3D bioprinting sheets of skin that can heal burn wounds.
A payload containing 3D printed supplies for the 3D BioFabrication Facility (BFF) has arrived on board the International Space Station (ISS) docked 248 miles above the Earth’s surface. The cargo contained samples of human cells, bio-inks, and a set of new 3D printed ceramic fluid manifolds to replace the previously used printed polymers.
UPM, a Finnish alternative energy and material company, has launched a range of bioinks known as GrowInk, designed for various 3D bioprinting applications such as tissue engineering and regenerative medicine.
Researchers at the Wake Forest Institute for Regenerative Medicine (WFIRM) in North Carolina have 3D bioprinted a microscopic model of the human body containing most of the vital organs. The miniature system will be used to detect potentially harmful effects of drugs before they are trialed with humans.
Biomedical engineers from Rutgers University in New Jersey have developed a bio-ink for 3D printing that enables the construction of scaffolds to support growing human tissues. Significantly, the stiffness of the scaffolds can be controlled depending on the mixture of ink used, enabling applications for different types of tissues for repair or replacement.
Sciperio, the research arm of micro-3D printing equipment manufacturer nScrypt, has announced a collaborative project to manufacture on-demand transfusion-safe human blood using nScrypt’s SmartPump technology.
Researchers from The University of Queensland in Australia have released a study which calls for clarification around the regulation of 3D printed devices that are used in the medical industry. The research team argues that as the healthcare market in 3D printing matures, and an increasing number of products get to market, there needs to be a greater deal of clarity and cooperation between manufacturers and regulators.
Spanish football club FC Barcelona’s R&D lab, Barça Innovation Hub, has joined the EU-backed ‘TRIANKLE’ project to help test its upcoming 3D bioprinted cell-restoring ankle implants.
Researchers from the Korea-based Asan Medical Center have 3D printed surgical guides that could help cancer patients to retain more of their breasts after surgery.
Researchers from the New York-based Clarkson University have developed a custom bioink and deployed it to create a range of skin-compatible 3D printed biosensors.
Biotechnology firm United Therapeutics and Israeli bioprinting firm CollPlant have broadened their partnership to enter into the serial manufacturing of 3D printed kidneys.
Using 3D printers, researchers have collaborated from around the globe to develop nanoclay-based 3D bioprinted scaffolds which could be used to aid skeletal regeneration.
Canadian 3D bioprinting company Aspect Biosystems has launched a new grant program whereby the selected applicants will be supplied with the company’s proprietary RX1 bioprinters.
Researchers from the Delft University of Technology in the Netherlands have discovered 3D printed biodegradable magnesium scaffolds could have promising applications in the regeneration of critical-sized bone defects.
South Korean pharmaceutical company HK inno.N has announced plans to use artificial 3D printed skin to test new autoimmune and skin disorder drugs.
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