Engineered Skin Substitutes Edge Closer to Clinical Reality
Researchers are advancing lab-grown skin substitutes that could reshape treatment for burns and chronic wounds. A comprehensive overview of this progress, published in Nature Outlook: Skin, highlights how multilayer grafts are moving closer to clinical use. In 2023, Anthony Atala at Wake Forest University School of Medicine in Winston-Salem, North Carolina, reported a printed three-layer graft that included pigment cells, vasculature, and hair follicles. In pigs, these grafts successfully merged with host tissue. “Why don’t we engineer skin that is full thickness, so you can actually use that as a permanent graft — just like you would a patient’s own graft?” Atala asks.