{"id":189147,"date":"2022-04-05T00:00:00","date_gmt":"2022-04-05T00:00:00","guid":{"rendered":"https:\/\/facfox.com\/news\/microfluidic-devices-fabricated-by-researchers-using-3d-printing-medical\/"},"modified":"2022-05-30T03:00:39","modified_gmt":"2022-05-30T03:00:39","slug":"microfluidic-devices-fabricated-by-researchers-using-3d-printing-medical","status":"publish","type":"post","link":"https:\/\/facfox.com\/news\/microfluidic-devices-fabricated-by-researchers-using-3d-printing-medical\/","title":{"rendered":"Microfluidic Devices Fabricated by Researchers Using 3D Printing"},"content":{"rendered":"<p>Researchers at the University of Southern California Viterbi School of Engineering have developed a highly specialized <a href=\"https:\/\/facfox.com\/service\/3d-printing-service\" target=\"_blank\" rel=\"noopener\">3D printing<\/a> technique (using vat photopolymerization technology) that allows microfluidic channels to be fabricated on chips at a precise microscale not previously achieved.<\/p>\n<p><iframe title=\"In-situ Transfer Vat Photopolymerization for Transparent Microfluidic Device Fabrication\" width=\"500\" height=\"281\" src=\"https:\/\/www.youtube.com\/embed\/bmbMU-z5xyA?feature=oembed\" frameborder=\"0\" allow=\"accelerometer; autoplay; clipboard-write; encrypted-media; gyroscope; picture-in-picture; web-share\" referrerpolicy=\"strict-origin-when-cross-origin\" allowfullscreen><\/iframe><\/p>\n<p>Microfluidic devices are compact testing tools made up of tiny channels carved on a chip, which allow bio<a href=\"https:\/\/facfox.com\/news\/topics\/medical\" target=\"_blank\" rel=\"noopener\">medical<\/a> researchers to test the properties of liquids, p<a href=\"https:\/\/facfox.com\/news\/topics\/art\" target=\"_blank\" rel=\"noopener\">art<\/a>icles, and cells at a microscale. They are crucial to drug development, diagnostic testing, and <a href=\"https:\/\/facfox.com\/news\/topics\/medical\" target=\"_blank\" rel=\"noopener\">medical<\/a> research in areas such as cancer, diabetes, and now COVID-19.<\/p>\n<p>However, the production of these devices is very labor-intensive, with minute channels and wells that often need to be manually etched or molded into a transparent resin chip for testing. While <a href=\"https:\/\/facfox.com\/service\/3d-printing-service\" target=\"_blank\" rel=\"noopener\">3D printing<\/a> has offered many advantages for bio<a href=\"https:\/\/facfox.com\/news\/topics\/medical\" target=\"_blank\" rel=\"noopener\">medical<\/a> device manufacturing, most techniques were not sensitive enough to build layers with the minute detail required for microfluidic devices. Until now.<\/p>\n<p>The University of Southern California research, led by Daniel J. Epstein Dep<a href=\"https:\/\/facfox.com\/news\/topics\/art\" target=\"_blank\" rel=\"noopener\">art<\/a>ment of Industrial and Systems Engineering Ph.D. graduate Yang Xu and Professor of Aerospace and Mechanical Engineering and Industrial and Systems Engineering Yong Chen, of the Viterbi School of Engineering, in collaboration with Professor of Chemical Engineering and Materials Science Noah Malmstadt and Professor Huachao Mao at Purdue University, was published in Nature Communications.<\/p>\n<p>\u201cAfter light projection, we can basically decide where to build the p<a href=\"https:\/\/facfox.com\/news\/topics\/art\" target=\"_blank\" rel=\"noopener\">art<\/a>s (of the chip), and because we use light, the resolution can be rather high within a layer. However, the resolution is much worse between layers, which is a critical challenge in the building of microscale channels,\u201d Chen said, \u201cThis is the first time we\u2019ve been able to print something where the channel height is at the 10 micron level; and we can control it really accurately, to an error of plus or minus one micron. This is something that has never been done before, so this is a breakthrough in the <a href=\"https:\/\/facfox.com\/service\/3d-printing-service\" target=\"_blank\" rel=\"noopener\">3D printing<\/a> of small channels\u201d.<\/p>\n<p>When it comes to microfluidic devices, vat photopolymerization has some disadvantages in the creation of the tiny wells and channels that are required on the chip. The UV light source often penetrates deeply into the residual liquid resin, curing and solidifying material within the walls of the device\u2019s channels, which would clog the finished device.<\/p>\n<p><img decoding=\"async\" id=\"thepasted-1\" class=\"aligncenter\" src=\"https:\/\/img.facfox.com\/imgs\/2022\/05\/30\/3b953622678a3b1b.png\" \/><\/p>\n<p>\u201cWhen you project the light, ideally, you only want to cure one layer of the channel wall and leave the liquid resin inside the channel untouched; but it\u2019s hard to control the curing depth, as we are trying to target something that is only a 10-micron gap,\u201d Chen said.<\/p>\n<div style=\"background-color: #eaeaea7a; padding: 15px 30px; align-items: center; border-radius: 4px; margin-top: 1em; margin-bottom: 1em;\">\n<div style=\"flex: 1; padding-right: 30px;\">\n<h4 style=\"margin-bottom: 14px;\">Manufacturing on Demand<\/h4>\n<div>Order custom parts through our online manufacturing network. Low cost, fast delivery. Upload your design for free quotes now!<\/div>\n<\/div>\n<p><a style=\"background-color: #0baee8; color: white; padding: 10px 20px; border-radius: 4px;\" href=\"https:\/\/facfox.com\" target=\"_self\" rel=\"noopener noreferrer\"><i class=\"fa-fw auxicon auxicon-cloud-upload\" aria-hidden=\"true\"><\/i> Get Quote<\/a><\/p>\n<\/div>\n<p>He said that current commercial processes only allowed for the creation of a channel height at the 100 microns level with poor accuracy control, due to the fact that the light penetrates a cured layer too deeply unless you are using an opaque resin that doesn\u2019t allow as much light penetration.<\/p>\n<p>\u201cBut with a microfluidic channel, typically you want to observe something under microscope, and if it\u2019s opaque, you cannot see the material inside, so we need to use a transparent resin,\u201d Chen said.<\/p>\n<p>To accurately create channels in clear resin at a microscale level suitable for microfluidic devices, the team developed a unique auxiliary platform that moves between the light source and the printed device, blocking the light from solidifying the liquid within the walls of a channel, so that the channel roof can then be added separately to the top of the device. The residual resin that remains in the channel would still be in a liquid state and can then be flushed out after the printing process to form the channel space.<\/p>\n<p>Microfluidic devices have increasingly important <a href=\"https:\/\/facfox.com\/news\/topics\/insights\/applications\" target=\"_blank\" rel=\"noopener\">application<\/a>s in <a href=\"https:\/\/facfox.com\/news\/topics\/medical\" target=\"_blank\" rel=\"noopener\">medical<\/a> research, drug development, and diagnostics.<\/p>\n<p>\u201cThere are so many <a href=\"https:\/\/facfox.com\/news\/topics\/insights\/applications\" target=\"_blank\" rel=\"noopener\">application<\/a>s for microfluidic channels. You can flow a blood sample through the channel, mixing it with other chemicals so you can, for example, detect whether you have COVID or high blood sugar levels,\u201d Chen said.<\/p>\n<p>He said the new <a href=\"https:\/\/facfox.com\/service\/3d-printing-service\" target=\"_blank\" rel=\"noopener\">3D printing<\/a> platform, with its microscale channels, allowed for other <a href=\"https:\/\/facfox.com\/news\/topics\/insights\/applications\" target=\"_blank\" rel=\"noopener\">application<\/a>s, such as p<a href=\"https:\/\/facfox.com\/news\/topics\/art\" target=\"_blank\" rel=\"noopener\">art<\/a>icle sorting. A p<a href=\"https:\/\/facfox.com\/news\/topics\/art\" target=\"_blank\" rel=\"noopener\">art<\/a>icle sorter is a type of microfluidic chip that makes use of different sized chambers that can separate different sized p<a href=\"https:\/\/facfox.com\/news\/topics\/art\" target=\"_blank\" rel=\"noopener\">art<\/a>icles. This could offer significant benefits to cancer detection and research.<\/p>\n<p>\u201cTumor cells are slightly bigger than normal cells, which are around 20 microns. Tumor cells could be over 100 microns,\u201d Chen said. \u201cRight now, we use biopsies to check for cancer cells; cutting organ or tissue from a patient to reveal a mix of healthy cells and tumor cells. Instead, we could use simple microfluidic devices to flow (the sample) through channels with accurately printed heights to separate cells into different sizes so we don\u2019t allow those healthy cells to interfere with our detection.\u201d<\/p>\n<p>Chen said that the University of Southern California Viterbi School of Engineering research team was now in the process of filing a patent <a href=\"https:\/\/facfox.com\/news\/topics\/insights\/applications\" target=\"_blank\" rel=\"noopener\">application<\/a> for the new <a href=\"https:\/\/facfox.com\/service\/3d-printing-service\" target=\"_blank\" rel=\"noopener\">3D printing<\/a> method and is seeking collaboration to commercialize the fabrication technique for <a href=\"https:\/\/facfox.com\/news\/topics\/medical\" target=\"_blank\" rel=\"noopener\">medical<\/a> testing devices.<\/p>\n<p>&nbsp;<\/p>\n<p style=\"font-size: 14px; color: grey;\">* This article is reprinted from <a href=\"https:\/\/www.3dprintingmedia.network\/microfluidic-devices-fabricated-by-researchers-using-3d-printing\/\" target=\"_blank\" rel=\"noopener\">3D Printing Media Network<\/a>. If you are involved in infringement, please contact us to delete it.<\/p>\n<p><i class=\"far fa-fw fa-user\"><\/i> Author:\u00a0Edward Wakefield<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Researchers at the University of Southern California Viterbi School of Engineering have developed a highly specialized 3D printing technique (using vat photopolymerization technology) that allows microfluidic channels to be fabricated on chips at a precise microscale not previously achieved.<\/p>\n","protected":false},"author":3,"featured_media":189148,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_monsterinsights_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0,"fifu_image_url":"\/wp-content\/uploads\/2022\/04\/3087805455246227248.jpg","fifu_image_alt":"","footnotes":""},"categories":[195],"tags":[24,129,67],"class_list":["post-189147","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-medical","tag-3d-printing","tag-medical","tag-micro-printing"],"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v27.2 (Yoast SEO v27.2) - https:\/\/yoast.com\/product\/yoast-seo-premium-wordpress\/ -->\n<title>Microfluidic Devices Fabricated by Researchers Using 3D Printing - FacFox News<\/title>\n<meta name=\"description\" content=\"Researchers at the University of Southern California Viterbi School of Engineering have developed a highly specialized 3D printing technique (using vat photopolymerization technology) that allows microfluidic channels to be fabricated on chips at a precise microscale not previously achieved. 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Researchers at the University of Southern California Viterbi School of Engineering have developed a highly specialized 3D printing technique (using vat photopolymerization technology) that allows microfluidic channels to be fabricated on chips at a precise microscale not previously achieved.","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/facfox.com\/news\/microfluidic-devices-fabricated-by-researchers-using-3d-printing-medical\/","og_locale":"en_US","og_type":"article","og_title":"Microfluidic Devices Fabricated by Researchers Using 3D Printing","og_description":"Researchers at the University of Southern California Viterbi School of Engineering have developed a highly specialized 3D printing technique (using vat photopolymerization technology) that allows microfluidic channels to be fabricated on chips at a precise microscale not previously achieved. 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